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Index > Protein center > Cd44(Gene name) > Mouse
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  • Cd44 (Gene name),
  • CD44 antigen (Protein name ),  CD44_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Cd44(Ly-24);
    Protein name:
    CD44 antigen;
    Alternative:
    GP90 lymphocyte homing/adhesion receptor;Extracellular matrix receptor III(ECMR-III);Hermes antigen;HUTCH-I;Lymphocyte antigen 24(Ly-24);Hyaluronate receptor;Phagocytic glycoprotein I(PGP-I);Phagocytic glycoprotein 1(PGP-1);
    CD:
    CD44;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    778
    Sequence:
    50:
    MDKFWWHTAW | GLCLLQLSLA | HQQIDLNVTC | RYAGVFHVEK | NGRYSISRTE | 
    100:
    AADLCQAFNS | TLPTMDQMKL | ALSKGFETCR | YGFIEGNVVI | PRIHPNAICA | 
    150:
    ANHTGVYILV | TSNTSHYDTY | CFNASAPPEE | DCTSVTDLPN | SFDGPVTITI | 
    200:
    VNRDGTRYSK | KGEYRTHQED | IDASNIIDDD | VSSGSTIEKS | TPEGYILHTY | 
    250:
    LPTEQPTGDQ | DDSFFIRSTL | ATIASTVHSK | SHAAAQKQNN | WIWSWFGNSQ | 
    300:
    STTQTQEPTT | SATTALMTTP | ETPPKRQEAQ | NWFSWLFQPS | ESKSHLHTTT | 
    350:
    KMPGTESNTN | PTGWEPNEEN | EDETDTYPSF | SGSGIDDDED | FISSTIATTP | 
    400:
    RVSARTEDNQ | DWTQWKPNHS | NPEVLLQTTT | RMADIDRIST | SAHGENWTPE | 
    450:
    PQPPFNNHEY | QDEEETPHAT | STTPNSTAEA | AATQQETWFQ | NGWQGKNPPT | 
    500:
    PSEDSHVTEG | TTASAHNNHP | SQRITTQSQE | DVSWTDFFDP | ISHPMGQGHQ | 
    550:
    TESKDTDSSH | STTLQPTAAP | NTHLVEDLNR | TGPLSVTTPQ | SHSQNFSTLH | 
    600:
    GEPEEDENYP | TTSILPSSTK | SSAKDARRGG | SLPTDTTTSV | EGYTFQYPDT | 
    650:
    MENGTLFPVT | PAKTEVFGET | EVTLATDSNV | NVDGSLPGDR | DSSKDSRGSS | 
    700:
    RTVTHGSELA | GHSSANQDSG | VTTTSGPMRR | PQIPEWLIIL | ASLLALALIL | 
    750:
    AVCIAVNSRR | RCGQKKKLVI | NGGNGTVEDR | KPSELNGEAS | KSQEMVHLVN | 
    778:
    KEPSETPDQC | MTADETRNLQ | SVDMKIGV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CD44 antigen
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    CLIA Kit for Mouse CD44 antigen
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    Polyclonal Antibody for Mouse CD44 antigen
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    Polyclonal Antibody for Mouse CD44 antigen
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    Polyclonal Antibody for Mouse CD44 antigen
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    Packing:
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    Polyclonal Antibody for Mouse CD44 antigen
    Polyclonal Antibody for Mouse CD44 antigen
    Monoclonal Antibody for Mouse CD44 antigen
    Monoclonal Antibody for Mouse CD44 antigen
    Monoclonal Antibody for Mouse CD44 antigen
    Monoclonal Antibody for Mouse CD44 antigen
    Monoclonal Antibody for Mouse CD44 antigen
    Protein for Mouse CD44 antigen
    Protein for Mouse CD44 antigen
    Protein for Mouse CD44 antigen
    Protein for Mouse CD44 antigen
    Protein for Mouse CD44 antigen

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    References
    1. 1.
      "Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition."
      He Q. , Lesley J. , Hyman R. , Ishihara K. , Kincade P.W.
      J. Cell Biol.119:1711-1719(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6; 7 AND 12)
      strain: DBA/2.
      tissue: Lung.
    2. 2.
      "Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor."
      Zhou D.F.H. , Ding J.F. , Picker L.J. , Bargatze R.F. , Butcher E.C. , Goeddel D.V.
      J. Immunol.143:3390-3395(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 13)
    3. 3.
      "Isolation of mouse CD44 cDNA: structural features are distinct from the primate cDNA."
      Nottenburg C. , Rees G. , St John T.
      Proc. Natl. Acad. Sci. U.S.A.86:8521-8525(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 13)
    4. 4.
      "Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7)."
      Wittig B.M. , Johansson B. , Zoeller M. , Schwaerzler C. , Guenthert U.
      J. Exp. Med.191:2053-2064(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 13)
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 13)
      strain: C57BL/6J.
      tissue: Embryo.
    7. 7.
      "The cDNA sequence of mouse Pgp-1 and homology to human CD44 cell surface antigen and proteoglycan core/link proteins."
      Wolffe E.J. , Gause W.C. , Pelfrey C.M. , Holland S.M. , Steinberg A.D. , August J.T.
      J. Biol. Chem.265:341-347(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-778 (ISOFORM 13)
    8. 8.
      "Splicing choice from ten variant exons establishes CD44 variability."
      Toelg C. , Hofmann M. , Herrlich P. , Ponta H.
      Nucleic Acids Res.21:1225-1229(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 224-637 (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8)
      strain: GR.
    9. 9.
      "The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat."
      Screaton G.R. , Bell M.V. , Bell J.I. , Jackson D.G.
      J. Biol. Chem.268:12235-12238(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 224-637 (ISOFORM 9)
      strain: BALB/c.
    10. 10.
      "A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44."
      Yu Q. , Toole B.P.
      J. Biol. Chem.271:20603-20607(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 10 AND 11)
      strain: Swiss Webster.
    11. 11.
      "Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes."
      Bourguignon L.Y. , Gilad E. , Peyrollier K. , Brightman A. , Swanson R.A.
      J. Neurochem.101:1002-1017(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PKN2;SUBCELLULAR LOCATION
    12. 12.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-726; SER-733 AND SER-742;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module."
      Terawaki S. , Kitano K. , Mori T. , Zhai Y. , Higuchi Y. , Itoh N. , Watanabe T. , Kaibuchi K. , Hakoshima T.
      EMBO J.29:236-250(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIAM1 AND TIAM2
    14. 14.
      "Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction."
      Banerji S. , Wright A.J. , Noble M. , Mahoney D.J. , Campbell I.D. , Day A.J. , Jackson D.G.
      Nat. Struct. Mol. Biol.14:234-239(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 23-174 ALONE AND IN COMPLEX WITH HYALURONAN;SUBUNIT;DISULFIDE BONDS
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